What is a Clinical Events Committee?
Clinical endpoints are chosen during trial design as events to measure to demonstrate the safety or efficacy of a therapy. To reduce variability, a charter of event definitions is drawn up. A CEC is an independent expert group tasked with reviewing and adjudicating suspected study endpoints to determine whether they meet the pre-specified definitions in the charter.
Why is a Clinical Events Committee so important?
The use of an independent blinded panel with appropriate expertise is essential to ensure the integrity of the data and that consistent, reliable adjudication-outcomes are obtained.